Doctor of Medical Science Danish Medical Bulletin

THIS THESIS IS BASED UPON THE FOLLOWING ORIGINAL PAPERS: 1. Schjoedt KJ, Andersen S, Rossing P, Tarnow L, Parving H-H. Aldosterone escape during blockade of the reninangiotensin-aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate. Diabetologia, 2004;47:1936-1939 2. Schjoedt KJ, Jacobsen P, Rossing K, Boomsma F, Parving H-H. Dual blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy: the role of aldosterone. Horm Metab Res. 2005;37 Suppl 1:4-8. 3. Schjoedt KJ, Rossing K, Juhl TR, Boomsma F, Rossing P, Tarnow L, Parving H-H. Beneficial impact of spironolactone in Diabetic Nephropathy. Kidney Int. 2005;68:2829-2836. 4. Schjoedt KJ, Lajer M, Andersen S, Tarnow L, Rossing P, Parving H-H. Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy. Scand J Clin Lab Invest. 2006;66:173-180. 5. Schjoedt KJ, Rossing K, Juhl TR, Boomsma F, Tarnow L, Rossing P, Parving H-H. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int. 2006;70:536-542. 6. Schjoedt KJ, Hansen HP, Tarnow L, Rossing P, Parving H-H. Long-term prevention of diabetic nephropathy: an audit. Diabetologia. 2008;51:956-961. 7. Schjoedt KJ, Astrup AS, Persson F, Frandsen E, Boomsma F, Rossing K, Tarnow L, Rossing P, Parving H-H. Optimal Dose of Lisinopril for Renoprotection in Type 1 Diabetic Patients with Diabetic Nephropathy. Diabetologia, 2009;52:46-49. 8. Schjoedt KJ, Christensen PK, Jorsal A, Boomsma F, Rossing P, Parving H-H. Autoregulation of glomerular filtration rate during spironolactone treatment in hypertensive patients with type 1 diabetes: a randomized crossover trial. Nephrol Dial Transplant 2009;24:3343-3349. ABREVIATIONS ABP, ambulatory blood pressure ACEI, ACE-inhibitor AngI, angiotensin I AngII, angiotensin II ARB, angiotensin II receptor blocker EH, essential hypertension ESRD, end-stage renal disease GFR, glomerular filtration rate RAAS, renin-angiotensin-aldosterone system RPF, renal plasma flow PA, primary aldosteronism PRA, plasma renin activity UACR, urinary albumin:creatinine ratio UAER, urinary albumin excretion rate